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Targeted Genetics Q4 loss grows, revenues fall (genetics news)

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The CATIE Study (genetics news)

... The authors themselves identified potential problems with the data resulting from the relatively low dosing of olanzapine, quetiapine, and ziprasidone as well as the absence of aripiprazole as a participant.

Corrected data indicated that ziprasidone and olanzapine did not differ significantly with respect to efficacy or discontinuation rates.

In the event of treatment failure, clozapine remained available to patients outside the study proper but was not itself included and thus precluded an important yardstick of antipsychotic action.

The late addition of ziprasidone limited its study period to less than those of the other drugs.

Even so, these findings as well as earlier work militate for a more thorough evaluation of ziprasidone and the other atypical antipsychotics that merit investigation under similar conditions (2).

The dose range of olanzapine exceeded the manufacturer’s recommendation (2.5–20 mg/day) by a factor of 150%, such that the mean dose, 20.8 mg/day, contrasted sharply with the other atypical medications, whose means remained substantially below their manufacturers’ recommended maxima.

Perphenazine use reached its manufacturer’s suggested maximum for hospitalized patients, 32 mg/day, but not the absolute safe limit of 64 mg/day (perphenazine prescribing information from Geneva Pharmaceuticals, Inc., Broomfield, Colo.).

Thus, olanzapine realized an advantage the other medications did not enjoy.

The role of geneti...

Models of Telepsychiatric Consultation�Liaison Service to Rural ... (genetics news)

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Full Text Models of Telepsychiatric Consultation–Liaison Service to Rural Primary Care Hilty et al.

Psychosomatics.2006; 47: 152-157.

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